Before treatment, 29 patients in the oral vitamin B12 group had neurologic symptoms related to vitamin B12 deficiency
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This is a particular concern with CKD because malnutrition is a recognised complication of kidney disease and worsens long-term outcomes
At week 30 the primary HbA1c endpoint was missing for 7%, 5% and 5% of patients and during the trial rescue medication was initiated by 14%, 2% and 1% of patients randomized to placebo, OZEMPIC 0.5 mg and OZEMPIC 1 mg, respectively
For reconstitution and storage, the co-lyophilized blend should be treated with the same care as TB-500 (the more fragile component)